I normally use a 3/0 Gamakatsu G-Lock hook for Zoom 6" lizards when I'm fishing open water or sparse cover. Now that Spring is in full swing there is a lot of shallow flooded vegetation. As a result I've been missing the hookset on a few fish. I've heard a lot of anglers increase the size of their hook when fishing cover. I thought of changing to a 4/0 G-Lock hook. Any input appreciated. Thanks.  

I fish Gamakatsu or X-Point 4/0 EWG Offset Worm Hooks most of the time.

I think it's hard to go too big unless it impedes the action of the bait.  That shouldn't be a problem with a lizard.

4/0 OWNER STRAIGHT SHANK WORM HOOK.