Toodie & Muldoon:  Car 54 Where Are You.  Unfortunately, I am old enough to remember.  

Frick and Frack:  A pair of swiss comedy ice skaters who performed in the thrities and forties.  Fortunately, I'm NOT old enough to remember.  I Googled that one.   ;D

I can't believe these haven't been said yet.

Tom and Jerry

Road Runner and Wile E. Coyote

Micky and Pluto

Rocky and Bullwinkle

Chester and Tweety

Jose and Manuel - Disney's Two Lazy Crows

Thanks Long Mike I knew you would get the Car 54 but thanks for the Frick and Frack explaination!

The Captin and Tenille

Joe Pass and Oscar Peterson

SAM AND DAVE

Peaches and Herb

Me and my Shadow

Two Mooks in a boat  

Those must be the 8-track prototypes for the iBoob....

I can't believe these haven't been said yet.

Tom and Jerry

Road Runner and Wile E. Coyote

Micky and Pluto

Rocky and Bullwinkle

Chester and Tweety

Gene, you and i think alike, yet you forget the most famous of all in my opinion,

Bugs and Daffy

Batman and Robin

Amos n Andy

Fibber Magee and Molly

Dagwood and blondie

How about those for some ole timers

captain and coke

gin & tonic

etc

Lone Ranger and Tonto

Thunder and Lightning

captain and coke

gin & tonic

etc

That's kinda what I was thinking..... ;D